Where can I buy tanning lotion or spray in Metro Manila, Philippines to cover my vitiligo spots on my hands?

Kindly include the place/store where I can buy them, the price, etc.


If you can recommend other products that can conceal my white spots(vitiligo) that will not stain my shirt or pants, please let me know. many thanks.Where can I buy tanning lotion or spray in Metro Manila, Philippines to cover my vitiligo spots on my hands?
Try Hawaiian Tropic royal tanning blend. It is available at the cosmetic counter of SM malls. I just cannot remember the price. Just follow the instructions on the bottle.Where can I buy tanning lotion or spray in Metro Manila, Philippines to cover my vitiligo spots on my hands?
Vitiligo


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Not to be confused with alphos, a form of leprosy once called vitiligo.


Vitiligo


Classification %26amp; external resources


Young woman with Vitiligo


ICD-10 L80.


ICD-9 709.01


OMIM 193200


DiseasesDB 13965


MedlinePlus 000831


eMedicine derm/453


Vitiligo (IPA /藢v瑟t蓹藞la瑟go/) or leukoderma is a chronic skin condition that causes loss of pigment, resulting in irregular pale patches of skin. The precise cause of vitiligo is complex and not fully understood. There is some evidence suggesting it is caused by a combination of auto-immune, genetic, and environmental factors. The population incidence in the United States is considered to be between 1% and 2%.[citation needed] It is considered a rare condition/rare disease that affects only 1 in 2,000 people.[citation needed]





According to Diseases Database: ';A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.';





Contents [hide]


1 Signs


2 Symptoms


3 Disease mechanism


4 Psychological effects


5 Treatment


6 Support organizations


7 Famous people with vitiligo


8 Vitiligo in domestic animals


9 See also


10 References


11 External links











[edit] Signs


Half of people with vitiligo develop patches of de-pigmented skin appearing on extremities before their 20s. The patches may grow, shrink, or remain constant in size. Patches often occur symmetrically across both sides on the body. Occasionally small areas may repigment as they are recolonised by melanocytes. The location of vitiligo affected skin changes over time, with some patches re-pigmenting and others becoming affected.





In some cases, mild trauma to an area of skin seems to cause new patches - for example around the ankles (caused by friction with shoes or sneakers). Vitiligo may also be caused by stress that affects the immune system, leading the body to react and start eliminating skin pigment.





Vitiligo on the scalp may affect the color of the hair (though not always), leaving white patches or streaks. It will similarly affect facial and body hair.








[edit] Symptoms


The following list of symptoms mentioned from various sources includes the 23 mentioned below:





Hand white patches


Feet white patches


Arm white patches


Face white patches


Lip white patches


Armpit white patches


Chest white patches


Back white patches


Shoulders white patches


Groin white patches


White patches around the mouth


White patches around the eyes


Nostril white patches


Navel white patches


Genital white patches


Mucous membrane white patches


Rectal white patches


Uveitis


Retina white patches


Premature graying


Gray scalp hair


Gray eyelashes


Gray eyebrows


Gray beard


Sun sensitivity





[edit] Disease mechanism


Vitiligo is associated with autoimmune and inflammatory diseases, commonly thyroid overexpression and underexpression. Jin in the New England Journal of Medicine reported a study comparing 656 people with and without vitiligo in 114 families, which found several mutations (single-nucleotide polymorphisms) in the NALP1 gene.[1][2] The NALP1 gene, which is on chromosome 17 located at 17p13, is on a cascade that regulates inflammation and cell death, including myeloid and lymphoid cells, which are white cells that are part of the immune response. NALP1 is expressed at high levels in T cells and Langerhan's cells, white cells that are involved in skin autoimmunity.





Among the inflammatory products of NALP1 are caspase 1 and caspase 5, which activate the inflammatory cytokine interleukin-1尾. Interleukin-1尾 is expressed at high levels in patients with vitiligo. There are compounds which inhibit caspase and interleukin-1尾, and so might be useful drugs for vitiligo and associated autoimmune diseases.





Of the 656 people, 219 had vitiligo only, 70 had vitiligo with autoimmune thyroid disease, and 60 had vitiligo and other autoimmune diseases. Addison's disease (typically an autoimmune destruction of the adrenal glands) may cause vitiligo.





In one of the mutations, the amino acid leucine in the NALP1 protein was replaced by histidine (Leu155-%26gt;His). The original protein and sequence is highly conserved in evolution, and found in humans, chimpanzee, rhesus monkey, and bush baby, which means that it's an important protein and an alteration is likely to be harmful.





The following is the normal DNA and protein sequence in the NALP1 gene:





TCA CTC CTC TAC CAA


Ser Leu Leu Tyr Gln


S L L Y Q





In some cases of vitiligo the first leucine is altered to histidine, by a Leu155鈫扝is mutation:





TCA CAC CTC TAC CAA


Ser His Leu Tyr Gln


S H L Y Q





(Leucine is nonpolar and hydrophobic; histidine is positively charged and hydrophilic, so it is unlikely to serve the same function.[3] [4])





The normal sequence of the DNA code for NALP1 of TCACTCCTCTACCAA is replaced in some of these vitiligo families by the sequence TCACACCTCTACCAA,[5] which respectively code for the amino acid sequence of the normal NALP1 protein SLLYQ being replaced by SHLYQ.[6]








[edit] Psychological effects


Vitiligo can have a significant effect on the psychological well being of the patient.[7] This is especially true for darker skinned patients as the contrast between pigmented and depigmented skin can be quite drastic.





In some cultures there is a stigma attached to having vitiligo. Those affected with the condition are sometimes thought to be evil or diseased and are sometimes shunned by others in the community. People with vitiligo may feel depressed because of this stigma or because their appearance has changed dramatically. Other people with vitiligo experience no negative psychological effects at all.








[edit] Treatment


There are a number of ways to alter the appearance of vitiligo without addressing its underlying cause. In mild cases, vitiligo patches can be hidden with makeup or other cosmetic camouflage solutions. If the affected person is pale-skinned, the patches can be made less visible by avoiding sunlight and the sun tanning of unaffected skin. However, exposure to sunlight may also cause the melanocytes to regenerate to allow the pigmentation to come back to its original color.





The traditional treatment given by most dermatologists is corticosteroid cream.[8]





Phototherapy may also beneficial using exposure to long-wave ultraviolet (UVA) light from the sun or from UVA, together with Psoralen, called ';PUVA';, Or with UVB Narrowband lamps (without Psoralen), can help in many cases. Psoralen can be taken in a pill 1-2 hours before the exposure or as a Psoralen soaking of the area 1/2 hour before the exposure. Lately, PUVA is being more and more replaced with exposure UVB Narrowband light at a wavelength of 311-313 nanometers. This treatment does not involve Psoralen since the effect of the lamp is strong enough. The source for the UVB Narrowband UVB light can be special fluorecent lamps that treat large area in few minutes, or high power fiber-optic devices in a fraction of a second.





Studies have also shown that immunomodulator creams such as Protopic and Elidel also cause repigmentation in some cases, when used with UVB Narrowband treatments.[9][10]





Alternatively, some people with vitiligo opt for chemical depigmentation, which uses 20% monobenzylether of hydroquinone. This process is irreversible and generally ends up with complete or mostly complete depigmentation.





In late October of 2004, doctors successfully transplanted melanocytes to vitiligo affected areas, effectively repigmenting the region. The procedure involved taking a thin layer of pigmented skin from the patient's gluteal region. Melanocytes were then separated out and used to make a cellular suspension. The area to be treated was then ablated with a medical laser, and the melanocyte graft applied. Three weeks later, the area was exposed to UV light repeatedly for two months. Between 73 and 84 percent of patients experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.[11]


OK personally if you just want to hide it there are numerous makeups available in multiple skin tones. Scope out a women's section in a quality store and show them the problem and ask for a cure. They will be more than happy to help you and very understanding. I would try Macy's or Merle Norman to start with. Also TV ads for covering age spots etc.